PittsburghV1, Main, Exploration, bibRecord, 000A00

Unraveling the miswired connectome: a developmental perspective.

Identifieur interne : 000A00 ( Main/Exploration ); précédent : 000999; suivant : 000A01

Unraveling the miswired connectome: a developmental perspective.

Auteurs : Adriana Di Martino [États-Unis] ; Damien A. Fair [États-Unis] ; Clare Kelly [États-Unis] ; Theodore D. Satterthwaite [États-Unis] ; F Xavier Castellanos [États-Unis] ; Moriah E. Thomason [États-Unis] ; R Cameron Craddock [États-Unis] ; Beatriz Luna [États-Unis] ; Bennett L. Leventhal [États-Unis] ; Xi-Nian Zuo [République populaire de Chine] ; Michael P. Milham [États-Unis]

Source :

Neuron [ 1097-4199 ] ; 2014.

RBID : pubmed:25233316

Descripteurs français

KwdFr :
- Connectome (), Encéphale (physiopathologie), Enfant, Humains, Modèles neurologiques, Troubles mentaux (physiopathologie).
MESH :
- physiopathologie : Encéphale, Troubles mentaux.
- Connectome, Enfant, Humains, Modèles neurologiques.

English descriptors

KwdEn :
- Brain (physiopathology), Child, Connectome (methods), Humans, Mental Disorders (physiopathology), Models, Neurological.
MESH :
- methods : Connectome.
- physiopathology : Brain, Mental Disorders.
- Child, Humans, Models, Neurological.

Abstract

The vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric in vivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach. Even more auspicious is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.

DOI: 10.1016/j.neuron.2014.08.050
PubMed: 25233316

Affiliations:

Le document en format XML

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<country xml:lang="fr">États-Unis</country>
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<front><div type="abstract" xml:lang="en">The vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric in vivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach. Even more auspicious is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.</div>
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Unraveling the miswired connectome: a developmental perspective.

Unraveling the miswired connectome: a developmental perspective.

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Abstract

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